ENGINEERED LIPOSOMES FOR NEUTRALIZATION OF SARS-COV-2 AND OTHER ENVELOPED VIRUSES
US20240139334
2024-05-02
Human necessities
A61K47/6911
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Drawings (4 of 7)
Smart overview of the Invention
This patent application describes engineered liposomes designed to neutralize enveloped viruses, including SARS-CoV-2. These liposomes are nanoparticles that can inhibit viral attachment and entry into host cells by utilizing surface-exposed cell receptor molecules. The invention aims to provide a treatment method for individuals infected with or at risk of infection from such viruses.
Background
The need for broad-spectrum antiviral treatments has become increasingly critical due to the global impact of viral outbreaks like COVID-19. Historically, the world has faced numerous viral epidemics, and the availability of effective antiviral drugs is limited to a small number of human viruses. Given the predicted rise in viral emergence due to globalization, developing versatile antiviral therapies is essential to mitigate future outbreaks.
Mechanism
The proposed method involves administering nanoparticles that carry cell receptor molecules capable of interacting with enveloped viruses. These molecules can be one or more from a list that includes ACE-2, CD4, and others. The nanoparticles may also contain DNA or RNA degrading reagents to further damage or destroy viral genetic material, thus preventing replication.
Applications
The liposomes can target a variety of enveloped viruses such as coronaviruses, influenza, and herpes simplex virus. They are designed for different modes of administration, including intravenous and intranasal routes, allowing them to be used in various clinical settings. This adaptability makes them suitable for treating infections directly at the site or systemically.
Components and Kit
The application also includes a kit comprising these engineered nanoparticles. The liposomes are typically unilamellar and range in size from 30 to 500 nm. They incorporate various cell receptor molecules and nucleic acid degrading agents, offering a comprehensive approach to neutralizing diverse enveloped viruses.