PHARMACOTHERAPY OF NEUROSYSTEM DYSFUNCTIONS

Smart overview of the Invention

A novel drug delivery system (DDS) is designed to release neurological drugs specifically in targeted regions of the brain, triggered by physiological changes induced by interactive tasks. These tasks, presented via audio or visual media, aim to create specific local physiological conditions like changes in pH, lactate levels, blood flow, temperature, or magnetic fields. This targeted approach minimizes drug delivery to unaffected areas, reducing unwanted side effects and allowing for optimal dosing in the target region.

Background and Challenges

Neurological disorders such as schizophrenia and depression present significant treatment challenges due to the side effects of existing drugs. Traditional medications often affect the entire brain rather than targeting specific areas, leading to adverse effects like abnormal movements, endocrine issues, weight gain, and sedation. These side effects limit drug dosages and can even prevent new drugs from gaining regulatory approval. The need for more precise treatments is evident given the high failure rate of CNS drugs in clinical trials.

Mechanism of Action

The DDS operates by attaching a neurological drug to a system that releases it in response to local physiological factors altered by a subject's interaction with a task. Tasks could include video games or puzzles that change specific brain chemistry markers. This innovative method allows for the precise targeting of drug release, potentially improving treatment outcomes while minimizing side effects by focusing on affected brain regions.

Adaptive Treatment Approach

The system includes a monitoring component that continuously assesses neurosystem function, allowing for dynamic adjustment of treatment strategies. This adaptability ensures that as a patient's condition evolves, so too can the therapy, optimizing drug release sensitivity and specificity. The DDS may also incorporate sustained-release mechanisms for prolonged therapeutic effects even after task completion.

Applications and Implications

This method introduces an innovative approach to treating CNS disorders by engaging patients in tasks that naturally trigger drug release in targeted brain areas. By focusing on specific physiological changes, this technology offers a promising path toward reducing the side effects commonly associated with neurological pharmacotherapy. It represents a significant advancement in personalized medicine for neurological conditions.