METHOD FOR SUPPRESSING CANCER METASTASIS THROUGH ALTERATION OF ADHESION DEPENDENCE OF CANCER CELLS

Smart overview of the Invention

A method has been proposed to inhibit cancer metastasis by altering the adhesion dependence of cancer cells. The focus is on understanding the factors that influence cell adhesion, which plays a critical role in the spread of cancer. By targeting these factors, it becomes possible to significantly reduce the production of circulating tumor cells (CTCs) from primary tumors, thereby potentially decreasing cancer mortality rates.

Importance of Adhesion in Cancer Progression

Cancer metastasis occurs when cancer cells detach from the primary tumor and establish new tumors in distant sites, often through blood or lymphatic systems. This process is responsible for over 90% of cancer-related deaths. While various theories exist regarding the mechanisms of metastasis, including epithelial-mesenchymal transition (EMT), recent findings suggest that other pathways may also contribute to this phenomenon.

Identification of Target Genes

Research has identified specific genes that determine the adhesion characteristics of CTCs. These genes differentiate between adherent cells and those in suspension. By manipulating the expression of these genes, it is possible to convert adherent cells into suspension cells or vice versa, impacting their metastatic potential. This discovery provides a new approach to inhibit metastasis through targeted gene regulation.

Composition for Cancer Treatment

The proposed method includes a composition containing inhibitors for specific genes associated with CTCs. These inhibitors can take various forms, such as small interfering RNA (siRNA), microRNA (miRNA), and antisense oligonucleotides, which are designed to block gene expression at different levels. This innovative strategy aims not only to prevent cancer spread but also to offer potential diagnostic tools for monitoring metastasis or recurrence.

Potential Applications and Benefits

The implications of this research extend beyond treatment, as it also opens avenues for diagnosing cancer metastasis. By focusing on the adhesion dynamics of cancer cells and targeting specific genes, this method could lead to more effective therapies and improved patient outcomes. The ongoing exploration of these mechanisms promises significant advancements in cancer management and reduction in mortality rates.