METHOD FOR ANCHORING AND MODIFYING NANO-DRUG ON SURFACE OF LIVING CELL

Smart overview of the Invention

A novel method enables the anchoring and modification of nano-drugs on living cell surfaces. By introducing an active reactive group to the cell surface through a hydrophobic tail chain of a cell membrane anchoring molecule, the nano-drug's surface is then modified to facilitate a biological orthogonal click reaction. This process effectively anchors the nano-drug to the cell, resulting in a modified living cell enriched with therapeutic agents.

Technical Field

This method falls within the biotechnology sector, specifically targeting the enhancement of nano-drug delivery systems. The approach aims to address existing limitations in conventional drug delivery methods, which often struggle with low targeting efficiency and suboptimal clinical efficacy.

Background and Challenges

Despite advancements in nanotechnology and the introduction of various nano-drugs since 1964, challenges remain in achieving effective drug delivery. Only a small percentage of administered drugs reach their intended target due to physiological barriers. Current methods for loading nano-drugs onto cells include chemical reactions, glycosylation, genetic engineering, and physical methods, each with significant drawbacks such as complexity, time consumption, and potential interference with normal cell functions.

Method Summary

The proposed method introduces an active reactive group onto living cells using a cell membrane anchoring molecule. This is followed by modifying the nano-drug's surface with a corresponding reactive group. A biological orthogonal click reaction then occurs between these groups, successfully anchoring the nano-drug to the cell surface. This innovative approach promises improved therapeutic outcomes by utilizing living cells as delivery vehicles for nano-drugs.

Applications and Therapeutic Potential

The application of this method could revolutionize treatment strategies for various diseases by creating living cells that are modified with potent nano-drugs. Target cells may include T cells and other immune cells, enhancing their therapeutic capabilities. The versatility of this technology opens avenues for combining various therapeutic agents, including hydrophobic and hydrophilic drugs, proteins, and gene therapies, thus providing a robust platform for future medical advancements.