CORONAVIRUS ANTIBODY

Smart overview of the Invention

An antibody has been developed that specifically targets the spike protein S2 domain of various coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2. These antibodies are significant for diagnosing and treating infections caused by these viruses. The application also covers various compositions that include these antibodies, such as pharmaceutical and diagnostic compositions, along with kits for practical use.

Coronaviruses and Public Health Threats

Coronaviruses, particularly SARS-CoV-2, have emerged as critical pathogens affecting public health. Previous outbreaks of SARS and MERS demonstrate the need for effective treatments and detection methods. The increasing interaction between humans and animal reservoirs raises the risk of new zoonotic infections, highlighting the urgency of addressing coronavirus-related health threats.

Monoclonal Antibodies as a Solution

Monoclonal antibodies (mAbs) are gaining traction as potential treatments for viral infections due to their ability to bind specifically to viral antigens. While many mAbs are strain-specific, the development of broadly neutralizing antibodies is essential for effective treatment against diverse coronavirus strains. The newly developed antibodies show promise in addressing this gap.

Cross-Reactivity and Neutralizing Activity

The antibodies exhibit robust cross-reactivity with multiple coronavirus strains and demonstrate neutralizing activity against each strain tested. This capability positions them as universal antibodies that can be utilized for both detection and treatment of known coronaviruses, as well as potential future strains that may emerge.

Specific Binding Characteristics

The antibodies bind to specific regions within the spike protein S2 domain of coronaviruses, which includes amino acid sequences defined in the application. The precise targeting of these regions enhances their effectiveness in neutralizing viral activity and contributes to the development of comprehensive diagnostic and therapeutic strategies against coronavirus infections.