COLOROMETRIC SENSOR FOR THE NON-INVASIVE SCREENING OF GLUCOSE IN SWEAT IN PRE AND TYPE 2 DIABETES

Smart overview of the Invention

A novel colorimetric sensor is designed for non-invasive glucose monitoring in sweat, aimed at assisting individuals with prediabetes and Type 2 diabetes. The sensor consists of a patch that adheres to the skin, featuring an adhesive layer, a substrate with a glucose sensing complex, and a protective cover. The glucose sensing complex includes a chromogen that changes color in response to glucose levels, allowing easy visual detection or digital analysis via smartphones.

Technical Field and Background

This technology addresses the pressing need for effective diabetes management tools as diabetes rates are rising. Diabetes leads to severe health complications, necessitating regular monitoring of glucose levels. Conventional methods often involve invasive techniques like finger pricks, which can be painful and inconvenient. This innovation seeks to provide a painless alternative by measuring glucose levels through sweat, which is less invasive and more user-friendly.

Sensor Design and Functionality

The sensor features an adhesive layer that bonds to the skin while allowing sweat to migrate into the glucose sensing complex. The substrate layer collects sweat and contains an enzyme that reacts with glucose, producing a color change detected by the user. This setup allows for accurate measurement of low glucose concentrations in small sweat volumes, enhancing the sensor's practicality for everyday use.

User Interface Enhancements

To improve user interaction, the sensor incorporates various indicators such as wetness or volume markers that signal when enough sweat has been collected for testing. Additionally, a color key helps users interpret the results based on the color change corresponding to specific glucose levels. These features ensure that users can easily understand their glucose status without requiring medical expertise.

Manufacturing Method

The manufacturing process for the glucose sensor involves creating an adhesive layer with openings for sweat migration, followed by layering a substrate with the glucose sensing complex. Options include preloading compounds to enhance sensitivity and buffering pH levels for optimal enzyme activity. The final assembly includes spacer and cover layers designed to provide visibility of the sensing complex while protecting the functional elements of the patch.