US20240341310
2024-10-17
Human necessities
A01N47/44
Antipathogenic nanostructures are designed to reduce or eliminate pathogens on surfaces. These structures can be applied as coatings on various objects, including vehicles, buildings, and personal protective equipment. The focus is on creating a protective layer that effectively inactivates viruses and microbes, particularly in high-touch environments where transmission risks are elevated.
The nanostructures consist of compounds that include styrene units, N-alkylacrylamide units, and specific moieties that enhance their effectiveness. These compounds may feature different alkyl substitutions and incorporate elements like guanidine and polygalactose, which contribute to their pathogen-targeting capabilities. The structure allows for a mechanical interaction with viral membranes, leading to their disruption and subsequent inactivation.
The proposed mechanism involves the nanostructure binding to the viral particles, causing significant conformational changes that rupture the viral membrane. This process not only inactivates the virus but also degrades its RNA, preventing further replication. The coatings have shown effectiveness against various strains of SARS-CoV-2 and other viruses, making them a versatile solution for pathogen control.
These nanostructures can be applied using methods such as spray-on coatings, which are environmentally friendly and suitable for large-scale manufacturing. Notably, coatings on personal protective equipment like masks have demonstrated complete inactivation of SARS-CoV-2 variants. The technology is adaptable for targeting a range of pathogens, ensuring broad-spectrum effectiveness in diverse settings.
The development of these antipathogenic coatings addresses critical public health needs by providing enhanced protection against airborne and surface-transmitted pathogens. With the ability to modify these nanostructures for targeting emerging viruses, there is potential for significant advancements in infection control measures across various industries, including healthcare and transportation.