Atomic Scale Topical Composition with Enhanced Interstitial Cellular Uptake for Increased Moisturizing, Fluidity, Antioxidant and Radiation Protection, Antimicrobial Cleansing and Therapeutics for Optimal Dermal Integrity and Homeostasis.

Smart overview of the Invention

A multifunctional topical composition integrates halogen-functionalized fullerenes and metallic nanoparticles (NPs) to enhance skin protection and therapeutic benefits. These components enable deeper tissue penetration, providing antioxidant, antimicrobial, and UV protective effects that support cellular integrity and differentiation. The formulation can penetrate the skin's outer layer and diffuse into deeper layers, delivering active ingredients through various pathways like sweat glands and hair follicles. Stable inorganic antibacterial agents are included for safety and efficacy, making the composition suitable for a range of skin-related applications.

Field of Application

The composition focuses on enhanced absorption in the skin's outer layers, offering broad-spectrum antimicrobial and antioxidant activity. It reduces pathogen burden, scavenges reactive oxygen species (ROS), and promotes cellular regeneration. Additionally, engineered fullerene nanoparticles protect against UVA rays, preventing photoaging and DNA damage. The invention also serves as an alcohol-free sanitizer and a topical therapeutic composition for wound management.

Background Information

Human skin acts as a barrier against toxins and pathogens, with its effectiveness influenced by factors like UV exposure and environmental conditions. Traditional skincare products often fail to reach deep skin layers, potentially leading to microbial accumulation and inflammation. Effective sunscreens should protect against both UVA and UVB radiation. Inorganic NPs offer advantages in skincare formulations, enhancing penetration and stability while providing safety over organic antibacterial agents.

Mechanism of Action

Understanding the skin's fluid pathways is crucial for developing effective topical formulations. Halogenated fullerenes increase polarity, allowing deeper tissue diffusion. NPs can penetrate the stratum corneum, reaching deeper layers due to their atomic size and properties. These particles are used in transdermal drug delivery systems to optimize drug delivery rates and reduce immunogenicity. The composition enhances penetration of macromolecular drugs while maintaining stability during the skin's renewal cycle.

Innovative Potential

Fullerenes serve as a platform for next-generation skincare innovations due to their unique electronic properties and structure. They offer versatile functionalization with exceptional antioxidant capacities at low concentrations. The scale, stability, and functionality of NPs improve penetration efficiency and biological interactions. Their inherent characteristics inspire innovation across biomedical and skincare industries by providing antioxidant, antimicrobial activity, and UV protection.