US20260294792
2026-10-01
Human necessities
A61K9/0021
Dissolvable microneedles (DMNs) are composed of biodegradable, water-soluble materials and are designed for painless skin application. They create microchannels in the skin, allowing encapsulated bioactive compounds to be released directly into the dermis. The microneedles dissolve upon contact with interstitial or mucosal fluid, providing systemic absorption of the compounds. This system offers advantages over traditional transdermal patches by enabling the delivery of larger molecules and providing sustained release of active ingredients. DMNs can deliver large molecules, such as phycocyanin encapsulated in solid lipid nanoparticles (SLNs), which would be challenging for standard transdermal systems.
The DMN system supports a wide range of bioactive agents, including vitamins, minerals, peptides, proteins, and synthetic molecules. It is suitable for therapeutic, cosmetic, veterinary, nutraceutical, and agricultural applications. The system addresses challenges like poor bioavailability and patient compliance associated with oral or injectable routes. It is particularly beneficial for populations with swallowing difficulties, malabsorption, or needle aversion. The DMN system offers a versatile, minimally invasive platform for precision bioactive administration, with customizable sizes and geometries for various applications.
Microneedle arrays can be customized in shapes, dimensions, and densities, allowing adaptation for diverse anatomical targets. The system can be configured in various forms, such as face masks, patches, or wearable fabrics. Each microneedle is made from biocompatible materials like hyaluronic acid or alginate, and may include stabilizing agents or excipients. The microneedles can have multiple parts for controlled release, and may include embedded indicators to show compound absorption. The system supports immediate, sustained, or biphasic release of bioactive compounds.
The DMN system is compatible with a variety of bioactive compounds, including proteins, peptides, antioxidants, and algae-derived substances like Spirulina. These compounds can be embedded in advanced carrier systems such as solid lipid nanoparticles, liposomes, or polymeric nanoparticles. This capability allows for the stabilization and controlled release of sensitive compounds. The system also supports agricultural applications, delivering bioactives to plants to enhance crop support and stress resistance.
The DMN system provides a scalable, stable, and biocompatible platform for the delivery of bioactive compounds across multiple fields. It improves bioavailability and patient compliance by offering a painless, self-administered alternative to oral or injectable routes. The system can address various health conditions, including nutrient deficiencies and inflammatory disorders, and support skin and scalp care. By enabling the delivery of larger bioactive molecules through the skin, the DMN system expands the possibilities for transdermal drug delivery.